Hubungan Pemberian Ekstrak Cordyline fruticosa L.A Cheval Terhadap Penurunan Kolesterol Tikus Putih

Dian Rahmawati

doi:10.24843/JFU.2020.v09.i03.p03

Dian Rahmawati Program Studi D3 Farmasi STIFA Pelita Mas Palu

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Abstrak

ABSTRACT

This study aims to determine the effect of ethanol extract of cordyline fruticose leaves in reducing total cholesterol levels of male white rats. This study used 30 male white rats which were divided into 6 treatment groups, each groups consistent of 5 test animals. Group I was normal control, group II was negative control (High cholesterol died and streptozotocin 30 mg/kgBW, group III was positive control (Simvastatin suspension), group IV, V, VI were each given an ethanol extract of cordyline fruticose leaves at a dose of 100 mg/kgBW, 150 mg/kgBW and 200 mg/kgBW for 14 consecutive days. Measurements of analyzed using a one-way statistical test (ANOVA) at 95% confidence level and continued with the Least Significant Difference (LSD) test to analyze differences between the groups. The result showed that the ethanol extract of cordyline fruticose leaves at a dose 200 mg/kgBW was able to reduce total cholesterol levels in white rats with cholesterol level of 39 mg/dL.

Keywords: High fat feed, Cordyline fruticosa, Cholesterol.

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Referensi

Afrilliani, D. A., Supriyanta, B., Rahayu, M., Analis, J., Poltekkes, K., Yogyakarta, K., … Group, C. (2014). Pengaruh Pemberian Rebusan Daun Salam (Eugenia polyantha Wight.) Terhadap Kadar Kolesterol Low Density Lipoprotein (LDL) Serum Tikus Putih (Rattus norvegicus) Hiperkolesterolemia. JURNAL TEKNOLOGI LABORATORIUM, 3.

Ayu, G., Tandi, J., & Nobertson, R. (2017). UJI EFEK EKSTRAK ETANOL DAUN KENIKIR ( Cosmos caudatus Kunth .) TERHADAP PENURUNAN KADAR KOLESTEROL PADA TIKUS WISTAR ( Rattus norvegicus ) DIABETES. Farmakologika Jurnal Farmasi, XIV(2).

Bogoriani, N. W., Putra-Manuaba, I. B., Suastika, K., & Wita, I. W. (2015). of Biomedical Pharmaceutical sciences PLASMA CHOLESTEROL AND BILE ACIDS LEVELS BY INCREASED THE EXCRETION OF FECAL TOTAL BILE ACIDS AND. European Journal of Biomedical and Pharmaceutical Sciences, 2(5), 122–134.

Kenta, Y. S., Tandi, J., T, B. L., & T, D. (2018). UJI EKSTRAK DAUN UBI JALAR UNGU (Ipomoea batatas) TERHADAP PENURUNAN KADAR KOLESTEROL TIKUS PUTIH. Farmakologika Farmasi Jurnal, XV(1).

Marbun, R. L. (2019). Potensi Pare ( Momordica charantia L ) Sebagai Penurun Kadar Kolesterol Darah Metode. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 188–192. https://doi.org/10.35816/jiskh.v10i2.147

Muchtaridi, Yanuar, A., Megantara, S. (2018). Kimia Medisinal: Dasar Dasar Dalam Perancangan Obat. Jakarta: Prenadamedia Grup.

Ofli, F., Chaudhry, R., Kurillo, G., Vidal, R., & Bajcsy, R. (2013). Berkeley MHAD: A comprehensive Multimodal Human Action Database. In IEEE (pp. 53–60). Tampa, FL: IEEE Workshop on Applications of Computer Vision (WACV). https://doi.org/DOI: 10.1109/WACV.2013.6474999

Putri, C. A., Yuliet, & Khaerati, K. (2018). EFEKTIVITAS EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL TIKUS PUTIH JANTAN (Rattus norvegicus L.) YANG DIINDUKSI PAKAN TINGGI LEMAK. Biocelebes, 12, 1–8.

Rahma, S., Natsir, R., Kabo, P., Keperawatan, I., Gorontalo, U. N., Biokimia, B., … Trigona, M. (2014). PENGARUH ANTIOKSIDAN MADU DORSATA DAN MADU TRIGONA TERHADAP PENGHAMBATAN OKSIDASI LDL PADA MENCIT HIPERKOLESTEROLEMIA. JST Kesehatan, 4(4), 377–384.

Ranti, G. C., Fatimawali, & Wehantouw, F. (2013). Uji Efektivitas Ekstrak Flavonoid dan Steroid Dari Gedi ( Abelmoschus Manihot ) Sebagai Anti Obesitas dan Hipolipidemik pada Tikus Putih Jantan Galur Wistar. Pharmacon, 2(2), 34–39.

Waloya, T., Rimbawan, & Andarwulan, N. (2013). Hubungan antara konsumsi pangan dan aktivitas fisik dengan kadar kolesterol darah pria dan wanita dewasa di bogor (. Jurnal Gizi Dan Pangan, 8(1), 9–16.

Widayanti, N. P., Puspawati, N. M., Suarsana, I. N., & Asih, I. A. R. A. (2016). AKTIVITAS ANTIOKSIDAN FRAKSI n -BUTANOL EKSTRAK KULIT TERONG BELANDA ( Solanum betaceum Cav .) SECARA IN VITRO DAN. Cakra Kimia (Indonesian E-Journal of Applied Chemistry), 4(1), 30–38.

Widiyantoro, A., & Destiarti, L. (2018). KARAKTERISASI FLAVONOID DARI FRAKSI ETIL ASETAT DAUN TANAMAN ANDONG ( Cordyline fruticosa ) DAN AKTIVITASNYA TERHADAP Plasmodium falciparum. Jurnal Kimia Khatulistiwa,7(3), 34–39.