POTENSI SIANIDIN POLY(LACTIC-CO-GLYCOLIC ACID)-POLYETHYLEN GLYCOL YANG DIMODIFIKASI FUSED FOLLICLE UNTUK MENINGKATKAN SENSITIVITAS DAN SEKRESI INSULIN DALAM MENANGANI PENYAKIT DIABETES MELITUS TIPE 2
Abstrak
ABSTRACT
Introduction: Type 2 diabetes mellitus is one of the four priority non-communicable diseases according to WHO. WHO data in 2015 showed that as many as 415 million people in the world suffer from type 2 diabetes mellitus. Even in Indonesia in 2013, the prevalence of people with diabetes has increased to 6.9%. Currently, the most common treatment for type 2 diabetes mellitus is the administration of metformin. However, long-term administration will cause lactic acidosis and kidney damage. Because of this, new alternatives are needed that minimize the side effects, for example by using herbal ingredients. Cyanidin is a natural flavonoid that has the effect of increasing insulin sensitivity and secretion.
Discussion: Cyanidin has the potential to increase insulin receptor sensitivity and increase insulin secretion. To increase insulin sensitivity, cyanidin can inhibit the downregulation of Glut4 expression and decrease the level of RBP 4 expression. As an increase in insulin secretion Cyanidin increases the expression of GLUT2, Kir6.2, and Cav1.2 genes that play a role in insulin secretion. Unfortunately, Cyanidin has low bioavailability and is unstable. Therefore, Cyanidin encapsulation will increase the availability of cyanidin in the blood and is easily concentrated into pancreatic cells
Conclusion: The Fc-modified Cyanidin PLGA-PEG combination has the potential to be a new alternative in the treatment of type 2 diabetes mellitus
Keywords: Type 2 Diabetes Mellitus, Cyanidin, Fc-modified Cyanidin PLGA-PEG
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Referensi
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26. Kobes J, Daryaei I, Howison C, Bontrager J, Sirianni R, Meuillet E et al. Improved Treatment of Pancreatic Cancer With Drug Delivery Nanoparticles Loaded With a Novel AKT/PDK1 Inhibitor. Pancreas. 2016;45(8):1158-1166.
27. Yamaguchi S, Katahira H, Osawa S, Nakamichi Y, Tanaka T, Shimoyama T, et al. Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. Am J Physiol Endcrinol Metab 2015;289:E643-9
28. Kamal, R., Novendrianto, D., Chadijah, F., Prasetya, G., Pratama, G., Ariadnya, M., Larasati, N., Darain, N., Nanda, O., Mavita, S., Usamah, U. and Prajitno, J. (2017). DIABETES RISK FACTOR SCREENING IN ADULTS USING PERKENI QUESTIONNAIRE AND ORAL GLUCOSE TOLERANCE TEST IN SOCAH COUNTY, BANGKALAN. Folia Medica Indonesiana, 53(3), p.199.
2. K D, years N, possible Y. Number of people living with diabetes doubles in twenty years [Internet]. Diabetes UK. 2018 [diakses 8 November 2018]. Dapat diakses di :https://www.diabetes.org.uk/about_us/news/diabetes-prevalence-statistics
3. Diabetes Drugs [Internet]. Diabetes.co.uk. 2018 [diakses 8 November 2018]. Dapat diakses di : https://www.diabetes.co.uk/Diabetes-drugs.html
4. List of Common Diabetes Medications [Internet]. Healthline. 2018 [diakses 8 November 2018]. Dapat diakses di : https://www.healthline.com/health/diabetes/medications-list
5. Metformin: medicine to treat type 2 diabetes - NHS.UK [Internet]. NHS.UK. 2018 [diakses 8 November 2018]. Dapat diakses di : https://beta.nhs.uk/medicines/metformin/
6. Abu Bakar M, Ismail N, Isha A, Mei Ling A. Phytochemical Composition and Biological Activities of Selected Wild Berries (Rubus moluccanusL.,R. fraxinifoliusPoir., andR. alpestrisBlume). Evidence-Based Complementary and Alternative Medicine. 2016;2016:1-10.
7. Suantawee, Tanyawan; T.Elazab, Sara; Hsu, Walter H. Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of L-type Voltage-Dependent Ca2+ Channel.Nutrients.2017, 9,814-828
8. Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T et al. Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochemical Pharmacology. 2008;74(11):1619-1627.
9. De Ferrars R, Czank C, Zhang Q, Botting N, Kroon P, Cassidy A et al. The pharmacokinetics of anthocyanins and their metabolites in humans. British Journal of Pharmacology. 2014;171(13):3268-3282.
10. Wang Y, Sun T, Zhang Y, Chaurasiya B, Huang L, Liu X et al. Exenatide loaded PLGA microspheres for long-acting antidiabetic therapy: preparation, characterization, pharmacokinetics and pharmacodynamics. RSC Advances. 2016;6(44):37452-37462.
11. Makadia H, Siegel S. Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Polymers. 2011;3(3):1377-1397.
12. Shi Y, Sun X, Zhang L, Sun K, Li K, Li Y et al. Fc-modified exenatide-loaded nanoparticles for oral delivery to improve hypoglycemic effects in mice. Scientific Reports. 2018;8(1).
13. Cyanidin [Internet]. Phytochemicals.info. 2019 [cited 2 January 2019]. Available from: http://www.phytochemicals.info/phytochemicals/cyanidin.php
14. Amin F, Shah S, Badshah H, Khan M, Kim M. Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ1–42-induced oxidative stress. Journal of Nanobiotechnology. 2017;15(1).
15. Li M, Panagi Z, Avgoustakis K, Reineke J. Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content. Int J Nanomedicine. 2012;7:1345–56.
16. Pridgen E, Alexis F, Kuo T, Levy-Nissenbaum E, Karnik R, Blumberg R et al. Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery. Science Translational Medicine. 2013;5(213):213ra167-213ra167.
17. Velioglu Y, Mazza G, Gao L, Oomah B. Antioxidant Activity and Total Phenolics in Selected Fruits, Vegetables, and Grain Products. Journal of Agricultural and Food Chemistry. 1998;46(10):4113-4117.
18. Zhishen J, Mengcheng T, Jianming W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chemistry. 1999;64(4):555-559.
19. Hoffman A. Corrigendum to “The early days of PEG, PEGylation (1970s–1990s)” [Acta Biomater. 40 (2016) 1–5]. Acta Biomaterialia. 2017;49:606.
20. Li W, Chen S, Zhou G, Li H, Zhong L, Liu S. Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach. Saudi Journal of Biological Sciences. 2018;25(3):500-506.
21. Jeon S, Han S, Lee J, Hong T, Yim D. The Safety and Pharmacokinetics of Cyanidin-3-Glucoside after 2-Week Administration of Black Bean Seed Coat Extract in Healthy Subjects. The Korean Journal of Physiology & Pharmacology. 2012;16(4):249.
22. Lawrence SA, Blankenship R, Brown R, Estwick S, Ellis B, Thangaraju A, et al. Influence of FcRn binding properties on the gastrointestinal absorption and exposure profile of Fc molecules. Bioorganic Med Chem [Internet]. 2021;32 (November 2020):115942. Available from: https://doi.org/10.1016/j.bmc.2020.115942
23. Rekha M, Sharma C. Oral delivery of therapeutic protein/peptide for diabetes – Future perspectives. International Journal of Pharmaceutics. 2013;440(1):48-62.
24. Banerjee A, Lee J, Mitragotri S. Intestinal mucoadhesive devices for oral delivery of insulin. Bioengineering & Translational Medicine. 2016;1(3):338-346.
25. Shrestha N, Araújo F, Shahbazi M, Mäkilä E, Gomes M, Airavaara M et al. Oral hypoglycaemic effect of GLP-1 and DPP4 inhibitor based nanocomposites in a diabetic animal model. Journal of Controlled Release. 2016;232:113-119.
26. Kobes J, Daryaei I, Howison C, Bontrager J, Sirianni R, Meuillet E et al. Improved Treatment of Pancreatic Cancer With Drug Delivery Nanoparticles Loaded With a Novel AKT/PDK1 Inhibitor. Pancreas. 2016;45(8):1158-1166.
27. Yamaguchi S, Katahira H, Osawa S, Nakamichi Y, Tanaka T, Shimoyama T, et al. Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. Am J Physiol Endcrinol Metab 2015;289:E643-9
28. Kamal, R., Novendrianto, D., Chadijah, F., Prasetya, G., Pratama, G., Ariadnya, M., Larasati, N., Darain, N., Nanda, O., Mavita, S., Usamah, U. and Prajitno, J. (2017). DIABETES RISK FACTOR SCREENING IN ADULTS USING PERKENI QUESTIONNAIRE AND ORAL GLUCOSE TOLERANCE TEST IN SOCAH COUNTY, BANGKALAN. Folia Medica Indonesiana, 53(3), p.199.
Diterbitkan
2022-07-20
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GORINTHA, Adrian Wiryanata; DEBORA, Stevina; CHANDRA, Natasya Eiffeline.
POTENSI SIANIDIN POLY(LACTIC-CO-GLYCOLIC ACID)-POLYETHYLEN GLYCOL YANG DIMODIFIKASI FUSED FOLLICLE UNTUK MENINGKATKAN SENSITIVITAS DAN SEKRESI INSULIN DALAM MENANGANI PENYAKIT DIABETES MELITUS TIPE 2.
Essence of Scientific Medical Journal, [S.l.], v. 20, n. 1, p. 19-26, july 2022.
ISSN 2655-6472.
Tersedia pada: <http://103.29.196.112/index.php/essential/article/view/78319>. Tanggal Akses: 04 mar. 2026
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